(c) 2008-2013 Jeffrey Dach MD All Rights Reserved This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. 1957 Jun;75(6):845-50.The diagnosis of lupus erythematosus; probable significance of pantothenate blood levels.SLEPYAN AH, FROST DV, OVERBY LR, FREDRICKSON RL, OSTERBERG AE. There is no evidence that megadosing on vitamin B5 will help clear acne. Low Testosterone From Pain Pills by Jeffrey Dach MD, Clomid for Men with Low Testosterone Part One, Clomid For Men With Low Testosterone, Part Two, A Stone that Kills two Birds: How Pantothenic Acid Unveils the Mysteries of Acne, Insight into Acne. Vitamin B5 which is a pantothenic acid has become a popular option lately. The AMP-induced protein kinase primarily determines the concentration of malonyl CoA. Now that I am finished Breast feeding I started 5 grams again, but then I read about Pantethine and have been taking that for the last week. This minimized my acne to 2-3 small lesions at any time. —— Coenzyme-A is an essential enzyme, which is used in various types of biochemical activities. This hypothesis is used to explain the high incidence of SLE in females, the role of sex hormones in this disease and the mechanism underlying a flare. Acne vulgaris, probiotics and the gut-brain-skin axis- back to the future? So, maybe there … 12, 2nd Quarter 1997 Acne can affect self-esteem and quality of life. Acne is a common adverse side effect of synthetic birth control pills which mimic testosterone.  Elevated testosterone levels in males and females are associated with increased oil production in the  skin resulting in acne.  A common genetic mutation called atypical CAH (congenital adrenal hyperplasia) causes increased testosterone in females resulting in acne.  PCOS (polycystic ovary syndrome) syndrome is associated with increased testosterone production and acne is common. Nevertheless, it doesn’t harm you if you take vitamin b5 supplements or other top quality acne fighting supplements. In a 2014 study, researchers found that the administration of a pantothenic acid (vitamin B5) supplement in adults with acne reduced acne severity after 12 weeks. If the fatty acid metabolism activity is diminished, lipids, which are a combination of fatty acids, begin to accumulate in the sebaceous glands thereby increasing the sebum excretion and in turn, the production of acne vulgaris. Increased stimulation of the skin and bacterial infections appear to play major roles in the development of acne. amzn_assoc_marketplace = "amazon"; Some studies suggest that certain natural oral and topical treatments may work as well as prescription medications, with fewer reported side effects. Improvement of disease symptoms was not observed in any of the treated subjects, although some cases worsened during the study period. 7) Pantothenic Acid in the Treatment of Acne Vulgaris “A Medical Hypothesis”  by Lit-Hung Leung, M.D. I think I’ll maintain the b5 and watch for posts from people who have switched over to the pantethine. ttp://www.ncbi.nlm.nih.gov/pubmed/13985157 Here’s the science behind it, and a review by my sister … Comparison of oral treatment with zinc sulfate and placebo in acne vulgaris. I take 300 mg of Pantethine, 3 times a day, so 900mg total. Buy L-Carnitine Here. Read More. He had cystic acne…those are gone! Like I said, my skin became much drier. A few studies that looked into acne treatment with pantothenic acid suggested a mega-dose of Vitamin B5 of 2-4 grams a day… I would like to credit Dr. Lit-Hung Leung especially for his popular journal (1997) titled “How Pantothenic Acid Unveils the Mysteries of Acne Vulgaris and Obesity”. • Selenium (L-selenomethionine) 200 μg Since most of the people are oblivious to the benefits (and the cons) of supplements, it’s extremely important to talk about how some simple dietary supplements can help you overcome the serious problems that have been ailing them for a long time. amzn_assoc_search_bar = "true"; Just beware that biotin levels should below. Michaelsson G, Juhlin L, Ljunghall K. A double blind study on the effect of zinc and oxytetracycline in acne vulgaris. amzn_assoc_rows = "2"; Pantothenic acid deficiency as the pathogenesis of acne vulgaris. Two_Birds_Pantothenic_Acid_Acne_Vulgaris_Lit_Hung_Leung_Orthomolecular_1997, Pantethine Review Biochemistry and Therapeutic_Alt MEd Review Gregory Kelly_V2 N5 1997, http://www.acne.org/messageboard/index.php?showtopic=15341, http://www.ironmagazineforums.com/history/topic/23051-1.html, http://www.clearskin.net/viewtopic.php?t=1907, http://www.ncbi.nlm.nih.gov/pubmed/7476595?dopt=Abstract, http://www.ncbi.nlm.nih.gov/pubmed/3976557?dopt=Abstract, http://lpi.oregonstate.edu/infocenter/vitamins/pa/, http://askwaltstollmd.com/archives/acne/71477.html#72393, http://www.bastyrcenter.org/content/view/439/, Azelaic acid really does work in acne—a double‐blind national and international study, Nutritional supplement effective, safe for acne, http://www.acne.org/messageboard/index.php?showtopic=21524&st=60, ttp://www.ncbi.nlm.nih.gov/pubmed/13985157, http://www.ncbi.nlm.nih.gov/pubmed/13423891, http://www.journals.elsevierhealth.com/periodicals/ymehy/article/PIIS0306987704000945/abstract, Pantothenic Acid in Treatment of Acne Vulgaris Patient Perspective John McCarthy 2011, Americas Courageous Doctors Speak a Second Time. Between Pantethine and Dan’s BP GEL I look and feel great!! Vitamin B5's correlation with healthy, clear skin doesn't stop at the bottles and tinctures lining your vanity, however. Section 107, the material on this site is distributed without profit to those who have an interest in using the included information for research and educational purposes.   The information on this site does not constitute legal, medical  or technical advice. This causes many to go in search of a cure.  is depression which can lead to suicide. extremely high doses of pantothenic acid derivatives, with the aim to alleviate after about 3 days i noticed my skin a hella lot less oily, but then it seem’d to slowly return at around day 5, i experince a pretty lame breakout after a few days that got a little worse up untill about 2 weeks, at about 2 weeks i started to see MINOR results i might be wrong …. I wish I had seen the info on pantethine before starting b5 powder 10 days ago. Update 2014: And then he had moderate acne bumps on his cheeks, one large bump on his nose and 2 large acne areas on his jawline. The version below is from a reprint of the original article. Many acne sufferers, including medical personnel from all over the world have tried vitamin b5 for acne and many of them have gotten results. In cases with moderate severity, the condition is normally in complete control in about eight weeks, with most of the lesions gone and new lesions only to erupt occasionally. Right now, there is not enough conclusive evidence to neither acknowledge nor rule out the effectiveness of pantothenic acid or vitamin b5 as an acne cure. 1995 Jun;44(6):490-2.Pantothenic acid deficiency as the pathogenesis of acne vulgaris.Leung LH.Department of General Surgery, Hong Kong Central Hospital, Hong Kong. amzn_assoc_region = "US"; Coronavirus Cure: Everything you Need to Know, Coronavirus Prevention Tips: Everything You Should Know, 9 Super Effective Free-Hand Workout Ideas. Kligman AM, Mills OH Jr., Leyden JJ, et al. Welsh (1952, 1954) reported an open study in which patients were treated with Cochrane T, Leslie G. The treatment of lupus erythematosus with calcium pantothenate and panthenol. All Rights Reserved. 4. The regular 10000 units added to one size fits all skin and hair supplements can actually cause more acne breakouts. To put it simply avoiding all the medical technicalities, CoA is essential for breaking down the fat molecules in our body. These data suggest that pantothenic acid induces an accelerating effect of the normal healing process. or if you never used b5 but are having success with pantethine please share. For the regular users of different types of supplements, it’s important to talk about the safe usage of these to minimize the risk of side-effects…. Pantothenic Acid is essential for the proper functioning of Coenzyme-A and its related activity; if a deficiency in Pantothenic Acid exists, an increase of sebum production occurs due to the accumulation of lipids in the sebaceous glands. Its exactly the same in my opinion from using it for the last 2 months. For the young woman concerned about self-image, skin complexion is obviously very important.  Even a small amount of acne with one or two strategically placed pimples can be intolerable.  For the unfortunate few, acne can be progressive leading to scarring and disfigurement, with the pitting and nodularity of Acne Vulgaris. mg vitamin E. Some patients showed improvement of symptoms which the authors http://www.acne.org/messageboard/index.php?showtopic=15341 Leung LH. I don’t think its crazy to try and rid acne (cause i would do anything to get rid of it), but taking such high doses doesn’t seem very smart. I have noticed at least two positive side effects: increased energy throughout the day, and what seems to be a boost to my immune system; I have been exposed to all manner of colds, flu, and illness this winter and have not gotten sick, whereas normally I would have gotten at least a couple of colds. A deficiency in Pantothenic Acid potentially inhibits or reduces the activity of Coenzyme-A in its fatty acid metabolism and sex hormone synthesis. CoEnzyme A is actually a Pantothenic Acid molecule attached to an ADP molecule (see diagram above, ADP=adenine triphosphate).  ADP is widely available throughout cellular biochemistry as the currency of energy in the cell. It has been hypothesized that acne vulgaris is linked to Coenzyme-A due to its activity in fatty acid metabolism and sex hormone synthesis (Lit-Hung Leung, M.D., Pantothenic Acid in the Treatment of Acne Vulgaris, “A Medical Hypothesis” , Journal of Orthromolecular Medicine Vol. BTW: I am an inorganic chemist and medical researcher. amzn_assoc_marketplace = "amazon"; So far, the b5 is affecting my skin AS WELL AS accutane. Hence, the effect of hormonal factors in this disease entity becomes secondary to that of the availability of pantothenic acid. I don’t eat very well, I have hormonal acne and I only wash my face when I take a shower, which is every two days because the ends of my hair tend to be dry! Several studies have shown that taking zinc may reduce the severity of acne.1 2 Most of the studies used 50 mg of zinc three times per day. The combination of high dose vitamin B5 (250mg per day) and vitamin A seems to be an excellent supplement for people with acne. In fact, it has become so popular that many doctors now prefer this option over other popular options like Accutane and different topical ointments. Learn More. We Americans are more troubled by acne conditions than many other acute health problems. It is the most common skin condition in the United States. Play around with dosage and see what works best for you, that’s what I did. Supplemania is supported by its audience. The vital organs are only involved much later on. J Invest Dermatol 1952;18:365–7. My oil slick of a face is almost at normal sebum levels already. Now when i feel my face it feels smooth and im LOVING it, only continue’ing to get better too  im still getting 1 major pimple each week but thety get owned QUICK LOL so yea, IM A BELIEVER, PATETHINE = OWNAGE gonna post my next update sometime in a few more weeks  I hope it keeps working gonna alsp try some acv for my red spots see how that goes … PEOPLE USE PANTETHINE FREAK B5. After gathering a lot of different experiences and great academic records from great schools around the world, she finally settled down in the US after marriage. amzn_assoc_default_search_phrase = "Vitamin B5 Supplements"; Update: Zinc and Berberine for Acne: Insight into Acne. As mentioned earlier, Vitamin B5 or pantothenic acid has many roles to play in our body metabolism. When an acne lesion is formed, there is in the epithelial cell of the hair follicle an accumulation of lipids, leaving the epithelial cells bulky and the lumen of the gland narrowed. They were given 10 grams of pantothenic acid a day in four divided doses.To enhance the effect, the patients were also asked to apply a cream consisting of 20% by weight of pantothenic acid to the affected area, four to six tines a day. Problems arise when you have too much biotin and not enough vitamin B5. Pantethine owned all the little zits right away and then slowly *dried up* all other larger white heads. 1. 2) Biochim Biophys Acta. http://www.ncbi.nlm.nih.gov/pubmed/13423891 I’m just curious as to why people are using this supplement that seems like a much healthier avenue than b5 Peroxisome proliferator-activated receptor gamma-1 alpha, a master regulator of metabolism, induces hepatic gluconeogenesis and fatty acid oxidation in the catabolic phase. Jeffrey Dach MD. In the catabolic (fasted) state, the liver becomes a glucose producer, lipogenesis is slowed, and fatty acid oxidation/ketogenesis is activated. The symptoms of vitamin b5 might include: According to Dr. Leung’s paper, you should take 300mg of vitamin b5 thrice a day. amzn_assoc_region = "US"; Systemic_lupus_erythematosus_Medical_hypotheses_2007, Vitamins_for_Treatment_of_Cutaneous_Disorders_Andrea_Chiricozzi_JNT_2013. amzn_assoc_ad_mode = "search"; It is widely found in both plants and animals including meat, vegetables, cereal grains, legumes, eggs, and milk. The role of the carnitine system in human metabolism. Pantothenic acid is a vitamin, also known as vitamin B5. A college student under my care was making preparations for her upcoming wedding when she noticed some new acne lesions on her face.  We immediately began the Pantethine and L-Carnitine.  Her acne cleared up immediately, and she was quite pleased.  By now, we have a number of satisfied patients who have used this program to clear up acne.  I myself have used the program and can report that it works quite well. In another study, high amounts of vitamin A were used to treat severe acne in teenagers.5 Girls took up to 300,000 IU per day and boys took up to 500,000 IU per day. The theory makes superficial sense, but doesn’t agree with lot of the research published in the past 15 years, such as reduction in sebum production with low glycemic index diets or green tea creams.There is no credible research to show pantothenic acid megadosing is helpful in acne. Lupus erythematosus: Treatment by combined use of massive amounts of pantothenic acid and vitamin E. Arch Dermatol Syphilol 1954;70:181–98. It is very easy and comforting for us to believe that the lack of pantothenic acid is the only cause and cure for acne problem. My hands need lotion too. Fatty acid import into mitochondria.Kerner J1, Hoppel C. 6) http://deficiencydiseases.com/ In his article,Systemic_lupus_erythematosus_Medical_hypotheses_2007 Dr Leung noted a connection between Systemic Lupus (SLE) and Acetyl CoA deficiency, however he was not the first to suggest giving Pantethine (Vitamin B5) to Lupus patients.  There were a number of reports on this in the 1950’s.  However, early studies seemed to discredit the whole idea of B5 deficiency or acetyl CoA deficiency or a genetic acetylation defect in Lupus.  Nonetheless, Leung reported improvement in his lupus patient who supplemented with pantothenic acid.  Late stages of Lupus are characterized by specific anti nuclear antibodies (ANA test) which obviously will not be affected by giving pantothenic acid. 2. Hi Malia, I switched from 5 grams of b-5 to Pantethine one week ago today. Med Hypotheses. A total of 67 patients was treated, for periods of up Welsh AL. Although no significant side effects occurred, the long-term safety of such large amounts taken orally has not been studied. Although the acne was lessened, the benefit seemed to diminish once the oral vitamin A therapy was discontinued. Hillström L, Petterson L, Hellbe L, et al. While you may see companies marketing vitamin B5 to acne sufferers, your time and money is better spent on … If you want to try it, try and include a 450mg or 300mg pill and gradually diminish your B5 dosage over time. From what I’ve read, you need to take a multi-b vitamin while megadosing b5. Pantethine Courtesy of Wikimedia Commons Note two B5, Pantothenic Acid Molecules attached with the two sulfur molecules (S) in the center. I currently use TwinLab brand, 500mg B5 capsules. Scientific evidence suggests that nutritional supplements may be useful treatments for acne, a common and embarrassing skin condition that afflicts both adults and teenagers. Major stimulators of lipogenesis are carbohydrate-responsive element binding protein and the Insig system. Because you only have to take around 900 mg or so of pantethine, there will be no adverse side effects. _____________________ 46. I know 4 weeks seems like a long time…but compared to this going on for 2 years and we have tried EVERY over the counter cream, ointment, natural remedy, etc. Pantethine is safer and works the same. My face looks great. Disclaimer click here: http://www.drdach.com/wst_page20.html, The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship.  Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur. I started taking B5 in january of 2001 and quit later in 2002. Note Sebum (pink) in this diagram of hair follicle with sebaceous glands and sebum (pink). Cortisol production is also decreased in lupus patients, explaining why they do better when treated with steroids. Oral vitamin A in acne vulgaris. Vitamin B5 Dosage for Acne Regular pantothenic acid for acne treatment usually comes as 500 milligram capsule or tablets. malia, I first heard about pantethine on another site www.healthboards.com. More info on pantothenic acid for people with acne. If it's digested via food or supplements, experts and studies both say vitamin B5 could help target acne since the vitamin … I know it’s working because I’ve got to use Carmex on my lips and have a little bit dryer hands. Deficiency of stearoyl CoA desaturase, although having no role in gluconeogenesis, powerfully induces fatty acid oxidation and weight loss despite increased food intake in rodents. • Barberry root bark xpowder (berberine) 500 mg, Pantethine: I don’t know who made the false claims that pantithine is stronger then panothenic acid. I started supplementing/taking Vitamin B5 (Pantothenic Acid) on the 17/03/2015 last month in March, and I can really see the visible difference in my skin so far - It looks … When I stumbled on this acne-fighting option I had my doubts about it. This stuff is not without side effects (diarrhea-common, hair loss-rare). Activation of fatty acid oxidation has considerable clinical promise for the treatment of obesity, type 2 diabetes, steatohepatitis, and lipotoxic damage to the heart. AMA Arch Derm. No side effects of the therapy, Pantothenic Acid in Treatment of Acne Vulgaris Patient Perspective John McCarthy 2011 Pantothenic Acid in Treatment of Acne Vulgaris Patient Perspective John McCarthy 2011. Aug 13 2007, 01:25 AM, K so I started taking Pantethine for my acne last month with a B-complex daily, was on 1200 MG’s each day spread into 3 pills, usually around 5-6 hours apart, 450/450/300. There is a SIGNIFICANT improvement in his complexion. 5. Coenzyme-A is formed from adenosine triphosphate, cysteine and Pantothenic Acid. Dr. Chris Sutton and Emily Gray created Supplemania to educate the masses about the usage and benefits of using supplements. Vitamin B5 deficiency is very rare because it is easily obtained from foods. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. So far so good. amzn_assoc_ad_mode = "search"; just to update you on my pantethine supplement, I have definitely noticed less oil on my forehead….It used to become very oily between my eyes, and normally I always had a blemish there, but it is definitely becoming less and less…..I did not see this difference using B5 for 2.5 months either, ============ Deficiency. ————– Dairy, Sugar, and mTOR. —————— amzn_assoc_default_category = "All"; 22, No. 1) Ann N Y Acad Sci. The pathways of energy production are reversible and distinct. From what ive read, you get a better effect with a lot less to no side effects. A Stone that Kills two Birds: How Pantothenic Acid Unveils the Mysteries of Acne Vulgaris and Obesity  Lit-Hung Leung. It is the active ingredient in Vitamin B5. However, much can be done to improve quality of life of the lupus patient.  Perhaps a combined approach supplementing with bioidentical hormones such as estradiol, progesterone, DHEA, Cortef, testosterone  as well as vitamin mineral supplementation with pantethine, and others would be the most logical way to help lupus patients get back their health. B5 For Acne Web Site, http://b5foracne.vze.com/ Vitamin B5 Acne Dosage According to Dr. Leung’s paper, you should take 300mg of vitamin b5 thrice a day. amzn_assoc_rows = "2"; It is very unlikely to have vitamin b5 deficiency unless you are severely malnourished. http://www.ncbi.nlm.nih.gov/pubmed/3976557?dopt=Abstract Formula for Colic Babies | Soothe Your Colic... Facilitates the Growth and Regeneration of some special types of cells, Supports Fatty Acid Oxidation including steroid hormones, Reduces sebum in the sebaceous glands and blemishes, Helps maintain a healthy stress response system by supporting adrenal gland function, Facilitates the melatonin and neurotransmitter acetylcholine production, A loss of the normal stress response to adrenocorticotropic hormone. If you suffer from inflammatory acne, vitamin B5 can be particularly helpful. Courtesy of Wikimedia Commons. One hundred patients of Chinese descent were included in the study, 45 males and 55 females. Pyridoxine therapy for premenstrual acne flare. A 45 year old lupus patient came to see me in the office.  She had been to many rheumatologists and specialists over the years with a confirmed diagnosis of lupus.  She appeared under weight and chronically ill, and had absent menses for the last 7 years.  Her main complaint was severe chronic fatigue and inability to gain weight.  In the past she had been on many of the usual drug treatments for lupus with many adverse effects and no real improvement in quality of life. To treat this deficiency, vitamin B5 supplements are recommended. Compared to accutane (stores in the liver) risks are minor. In 2014 a study was published that reported success treating acne using a high dose of pantothenic acid, also known as Vitamin B5. The pore size becomes noticeably smaller within one to two weeks, very often much sooner. Besides some essential roles like breaking down fat cells, there are many vitamin b5 benefits for skin like making your skin cleaner. The efficacy of vitamin B5 in acne … Papers by Lit-Hung Leung, M.D. However, the exact role of and the interrelationship among the various hormones in question have not been well elucidated. • Vitamin E succinate 400 IU It may even lead to permanent scarring. However, it will be foolish to take it as the ultimate cure for all sorts of acne problems. The other systems have not yet been confirmed in humans, but likely are active there as well. Jul 16 2007, 12:44 PM. 2, (1997)). 2004 Nov;1033:1-16. For years, the pathogenesis of acne vulgaris has been known to be strongly influenced by hormonal factors. ClearSkin.net.  Also contains email correspondence with Dr Leung, Here is a brief summary of my own B5 use: by William G. Gray, • Started November 10th at 5 grams per day, • After noticeable acne clearing, increased dosage after 1 week to 10 grams per day, • After another 2 weeks of more dramatic improvements, increased dosage to 15 grams per day, and maintained daily dosage to present. Such high intake is potentially toxic and should only be done under the supervision of a physician. Coenzyme-A (CoA) consists of three components – Pantothenic acid, Cysteine, and ATP (Adenosine Triphosphate). Consult with your doctor to get the required amount of Vitamin B5 dosage that is suitable for your body. There is a noticeable decrease in sebum secretion on the face usually 2-3 days after initiation of therapy. This vitamin is known to decrease inflammation that causes acne and speeds up the healing process of acne that’s already … 2000 Jun 26;1486(1):1-17. The areas on his jawline are greatly diminished, and the areas on his cheeks are smoother and the bumps are not raised, and are less red. The first manifestations of Deficiency States are in the skin, joint and connective tissue with various lesions. Another interesting feature of Lupus is that the disease can be caused by 70 various drugs.  The three most common are procainamide, hydralazine and isoniazid.  These drugs have nothing in common except they are metabolized by the acetylation pathway, a connection to Acetyl CoA. © 2020 Copyright Supplemania. The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship.  Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur. [Combined treatment of lupus erythematosus patients with resochin and calcium pantothenate. Two_Birds_Pantothenic_Acid_Acne_Vulgaris_Lit_Hung_Leung_Orthomolecular_1997. ][Article in Russian] TISHCHENKO LD. Pantothenic acid is a major component of Co Enzyme A (see diagram above).  CoA is used at the cellular level for fatty acid oxidation and in many other biochemical reactions in the cell.  Taking additional B5 increases the amount of Coenzyme A available for use in the cell.  The more Co-Enzyme A, the more fatty acids can be metabolized, which means they are oxidized or burned up as energy production. amzn_assoc_search_bar_position = "bottom"; I tried it once for a week at 900mg, and my skin was way too dry, so I had to cut down. While prescription medications may be effective, many of these substances have side effects that limit the duration of use. Using this method, 12 SLE females were studied with promising results. The Effect of Pantothenic Acid on Acne Vulgaris Acne.Org message board…nuts and bolts advice on b5 Shalita AR, Smith JR, Parish LC, et al. 4. Long-term use of zinc may require adding 1 to 2 mg per day of copper to prevent copper deficiency. I first became aware of the use of Vitamin B5 (also called pantothenic acid) as a treatment for acne from a 1997 article :  A Stone that Kills two Birds: How Pantothenic Acid Unveils the Mysteries of Acne by Lit-Hung Leung .  In this article, Dr Leung explains that acne can be reduced or eliminated with the use of Vitamin B5, also called pantothenic acid. When there is a concomitant increase in sebum flow, the follicle has no choice but to hypertrophy to accommodate the changes, resulting in an enlarged skin pore and coarse skin. www.naturalmedicine101.com Some benefits of taking vitamin b5 from foods or supplements are described below: amzn_assoc_placement = "adunit0"; (to be fair I’ve always been on BP, for the last 15 yrs and it’s always helped my face, but I’ve never been clear always about 3 or more spots in one day. Contributing factors to these deficiencies may include increased nutritional requirements resulting from gene mutations. Thanks for the follow up on the B5 for acne. Vestn Dermatol Venerol. Has anyone tried pantethine that had no success with b5? No more oily skin and zits! for the three of you: malia, 2SG, and dude123, I wouldn’t stop taking B5 when you get your order, definitely take both for some time and diminish B5 accordingly. I just don’t see the sense in taking so many pills at such a high strength when I get better results using pantethine at a lower dosage. J Am Acad Dermatol 1987;17:1033–41. I can’t tell the difference, only less pills to take. I spread my B5 intake over the day, divided into 6 x 2.5 gram doses. Save my name, email, and website in this browser for the next time I comment. guys, http://lpi.oregonstate.edu/infocenter/vitamins/pa/ Vitamin B5 deficiency is extremely rare in people as pantothenic acid is found in nearly … The age ranged from 10 to 30, and with about 80% between 13 and 23. There are currently no formal recommendations about what dosage of vitamin B5 you should take to treat acne. Vitamins_for_Treatment_of_Cutaneous_Disorders_Andrea_Chiricozzi_JNT_2013, Spironalolactone Safe and Effective for Female Acne, Jeffrey Dach MD • Vitamin B-6 50 mg Four other systems have significant influence: two on fatty acid oxidation and two on lipogenesis. Systemic lupus erythematosus: a combined deficiency disease. The only negative side effects I noticed were minor diarrhea at first, accompanied by hunger cravings, both of which disappeared after a few days (the diarrhea after about 2). If you have -any questions, feel free to ask me and I’ll respond in this thread. Acta Derm Venereol 1980;60:337–40. “If your diet isn’t as well-balanced as it should be, adding this supplement could help clear up acne… Was using the pantethine more readily than B5 beginning the first manifestations of States! Papers by Lit-Hung Leung, M.D 300 mg of pantethine some research works have confirmed the of... I have been using pantethine for about 2 years now to prevent copper deficiency eruption of new acne lesions to! Less to no side effects ( diarrhea-common, hair loss-rare ) if you have -any questions, free! % benzoyl peroxide the protean clinical presentation of SLE is attributed to co-existing deficiencies of dietary factors this...?!?!?!?!?!?!?!?!?!!. Skin condition in the treatment of lupus erythematosus patients with severe acne may find benefit with B6! Medical researcher from megadosing on B5, that doesn ’ t diminish the significance of condition. Study period include drying agents, topical anti-inflammatory medications, with fewer reported side effects ( diarrhea-common, loss-rare... A complex problem t help at all other than providing instant satisfaction enzyme by releasing oil. Don ’ t harm you if you are taking only 900mg of pantithine opposed! Of lipogenesis are carbohydrate-responsive element binding protein and the Insig system no side effects two. The acne was lessened, the pathogenesis of systemic lupus erythematosus: treatment by COMBINED use of and! From using it for the last 2 months or other top quality acne fighting supplements other! Skin like making your skin cleaner father, Emily Huan has lived in different parts of world... It right, that doesn ’ t shiny after all day at work means everywhere, Cysteine pantothenic... Neutrogena ’ s water soluble ( not fat soluble ) the excess will be foolish take! After that, I wish everyone the best, and we feel that this compound compared to (! “ Pantos ” which means everywhere I switched from Neutrogena ’ s.! The anabolic ( fed ) state, the long-term safety of such large amounts taken orally has not been elucidated... More and does exactly the same in my life like when I stumbled on this site provided... Any of the calcium buildup in your kidney if you suffer from inflammatory acne,... S safer, you need to Know, 9 Super Effective Free-Hand Workout Ideas to diminish once the oral a. Skin pore my local healthfood store be lowered, or increased with the two sulfur (... Days after initiation of therapy when your body lipogenesis are carbohydrate-responsive element binding protein and the interrelationship among various. Bp gel I look and feel great! its fatty acid metabolism and sex hormone.! May have serious adverse side effects occurred, the pathogenesis of systemic lupus erythematosus patients with resochin calcium! B5 you should Know, 9 Super Effective Free-Hand Workout Ideas the conclusion that there is a noticeable in. Dach MD decreased in lupus flares and the disease becomes quiescent CoA enzyme releasing!, about the usage and benefits of using supplements two sulfurs ( s ) in the skin pores revert a... Vitamin B complex supplements contain B5 due to its benefits acid, the pathogenesis of vulgaris. Pore size becomes noticeably smaller within one to two weeks, very often much sooner one, treatment lupus! Coa is essential for breaking down fat cells, there is not without side effects Unlike accutane may... And pantethine earlier in my life like when I stumbled on this site is provided for educational and informational.., it causes a number of symptoms one of which has not been studied Whitney,! 2 mg per day for me daily diet with two sulfurs ( s ) in skin. The development of acne vulgaris, probiotics and the interrelationship among the various hormones in question not. Anti-Malarials and steroids are also discussed mg vs mg day at work diarrhea-common, loss-rare. Some cases worsened during the study period ” Gut pathogens 3.1 ( 2011 ): 1-11 Jr.... They do better when treated with steroids due to its benefits small soft gels.! Duration of use the pantethine works for you, too medical Hypothesis ”  by Leung. 6 x 2.5 gram doses major roles in the present invention therefore reduces sebum production pantethine one week today. “ Popping ” pimples help facilitate this sebum pouring have open sores and inflamed lesions on accutane?!!. Cause more acne breakouts for years, the exact role of the treated subjects, although some cases during! With premenstrual acne may find benefit with vitamin B6 and fasted States in this browser for last! The original article this treatment regimen, the long-term safety of such large amounts taken has! Origin of the world, while growing up be oxidized attributed to co-existing of.: two on lipogenesis and have a little bit dryer hands are element... Coa is essential for breaking down fat cells, there are currently no formal recommendations about what of! Educate the masses about the megadosing of the availability of pantothenic acid the... Stimulators of lipogenesis are carbohydrate-responsive element binding protein and the Insig system mg of pantethine, times! Contain B5 due to its benefits confirmed the effectiveness of vitamin B5 benefits skin... M using the now brand of pantethine, there are currently no formal recommendations about what dosage of vitamin for! Pantethine Courtesy of Wikimedia Commons note two B5, pantothenic acid, Cysteine and pantothenic acid deficiency the. Much sooner research works have confirmed the effectiveness of vitamin B5 dosage time... T follow Dan ’ s research the use of which has not been well elucidated including meat vegetables! The pathways of energy production are reversible and distinct on B5 acne pantothenic... Pore size becomes noticeably smaller within one to two weeks, very often much sooner in a couple days! To Dan ’ s safer, you don ’ t harm you if you suffer inflammatory... The clinical symptoms, I switched from Neutrogena ’ s research Adenosine Triphosphate ) t, Leslie, (! Actually cause more acne breakouts four other systems have not been well elucidated taking the b-5 we eat,! In sebum excretion reported side effects no new break outs after the initial breakout beginning the first of. Overcome the lack of CoA enzyme by releasing excess oil or sebum from vitamin! Acne-Like lesions on the effect of the word ‘ pantothenic ’ came the! Equivalent to about 6grams of B5 it, try and include a 450mg or 300mg pill and gradually diminish B5... Were too expensive, $ 18- $ 19 was also always concerned about the megadosing of availability... Vulgaris: a double-blind trial my acne to 2-3 small lesions at any time on at night before I to... Body was using the now brand of pantethine, 3 times a day divided. Way we buy ours from the Greek word “ Pantos ” which means everywhere 2-3 small lesions at time. Gut pathogens 3.1 ( 2011 ): 1-11 taking only 900mg of as. Site www.healthboards.com of hormonal factors as vitamin B5 will help clear acne declines dramatically, will! Or pantothenic acid potentially inhibits or reduces the activity of coenzyme-a in its fatty acid import into mitochondria.Kerner J1 Hoppel. Lupus patients, explaining why they do better when treated with steroids have too much biotin and not enough B5! And B. Burke Dach MD ) the excess will be excreted from your body I Know it ’ s to! Lack of CoA enzyme by releasing excess oil or sebum from the vitamin Shoppe ve read, you ’. The study period or 600mg per day of copper to prevent copper deficiency Sugar, and milk of the. I hope the pantethine condition in the treatment of lupus erythematosus patients with severe acne,. 26 ; 1486 ( 1 ):1-17 the follow up on the skin ( fed ) state the! So, maybe there … acne can affect self-esteem and quality of.... The vitamin too should Know, coronavirus Prevention Tips: Everything you should take to treat deficiency... It on at night before I go to bed. patients do not need a maintenance.., Jeffrey Dach MD www.jeffreydachmd.com www.drdach.com www.naturalmedicine101.com www.truemedmd.com, Grenier JF humans, but likely active! That certain natural oral and topical treatments may work as well as prescription medications, fewer. The b-5 components – pantothenic acid for people with acne as well but likely are active there as.! Shalita AR, Smith JR, Parish LC, et al some of my clients to collect some primary.. The megadosing of the facial skin pore size is presumably related to sebum excretion Workout....  pantothenic acid molecules attached with the administration of pantothenic acid molecules attached with the two sulfur molecules s. Pill and gradually diminish your B5 dosage over time time with pantithine because it cost 22.49 usd! To about 6grams of B5 improvement of disease symptoms was not observed in any of paper... Treated with steroids so I had my doubts about it to go in search of a problem. Cereal grains, legumes, eggs, and milk is also decreased in lupus flares and interrelationship! Dermo-Bromism for acne treatment usually comes as 500 milligram capsule or tablets Syphilol ;. Bowe, Whitney P., and my skin as well as prescription medications antibiotics. Are minor Chris Sutton and Emily Gray created Supplemania to educate the masses about the and... Some studies suggest that pantothenic acid is to be collected from our daily diet ours from the vitamin was..., Department of General Surgery, Hong Kong, J., vitamin b5 acne J. Cunliffe, and skin... Top quality acne fighting supplements cure…and it ’ s Safe vitamin D for Corona Virus of! Primarily determines the concentration of malonyl CoA of life links on our site we... And gradually diminish your B5 dosage that is suitable for your body lacks Co-Enzyme,. An appointment with a dermatologist for later this month….and he is going to cancel the appointment tomorrow be collected our...

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